We combine single-cell live biosensor imaging, dynamic perturbations using microfluidics, and mathematical modelling to dissect how different growth factors control single-cell MAPK ERK dynamics to specify fate decisions.
We have been awarded a highly competitive Human Frontiers Science Program grant to study single cells Signaling Dynamics that regulate Stem Cell Renewal and Neuronal Fate decisions.
This is together with:
- Rafael Carazo-Salas at University of Bristol (https://research-information.bristol.ac.uk/en/persons/rafael-e-carazo-salas(a7638b29-53e4-49ba-82b5-98b21d82f41f).html)
- Andrew Cohen at Drexel University (https://drexel.edu/engineering/about/faculty-staff/C/cohen-andrew/)
Please check out our new accepted manuscript on automated neuronal growth cone segmentation in collaboration with the Danuser lab at UT Southwestern.
Congrats Maria, Ludo and Gaudenz …
We have been awarded a prestigious SNF Sinergia program grant to study feedback regulation from the cytoskeleton to Rho GTPase signaling. This work will take advantage of state-of-the-art live imaging techniques including biosensor imaging, non-neuronal optogenetics and chemical biology techniques.
This multidisciplinary work will be performed in collaboration with the labs of:
- Damian Brunner at UniZH (https://www.imls.uzh.ch/en/research/brunnerd.html)
- Daniel Riveline at IGBMC Strasbourg (http://www.igbmc.fr/riveline/),
- Karsten Kruse at UniGE (https://www.unige.ch/sciences/biochimie/labs/karsten-kruse/)